A small molecule p38α MAPK inhibitor, MW150, attenuates behavioral deficits and neuronal dysfunction in a mouse model of mixed amyloid and vascular pathologies. Frazier HN, Braun DJ, Bailey CS, Coleman MJ, Davis VA, Dundon SR, McLouth CJ, Muzyk HC, Powell DK, Rogers CB, Roy SM, Van Eldik LJ. Brain Behav Immun Health. 2024 Jul 23;40:100826. doi: 10.1016/j.bbih.2024.100826. eCollection 2024 Oct. PMID: 39161874 Free PMC article.
Early chronic suppression of microglial p38α in a model of Alzheimer’s disease does not significantly alter amyloid-associated neuropathology. Braun DJ, Frazier HN, Davis VA, Coleman MJ, Rogers CB, Van Eldik LJ. PLoS One. 2023 May 31;18(5):e0286495. doi: 10.1371/journal.pone.0286495. eCollection 2023. PMID: 37256881 Free PMC article.
Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology. Braun DJ, Powell DK, McLouth CJ, Roy SM, Watterson DM, Van Eldik LJ. PLoS One. 2022 Jan 26;17(1):e0262474. doi: 10.1371/journal.pone.0262474. eCollection 2022. PMID: 35081152 Free PMC article.
Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease. Braun DJ, Dimayuga E, Morganti JM, Van Eldik LJ. J Neuroinflammation. 2020 Sep 17;17(1):274. doi: 10.1186/s12974-020-01938-7. PMID: 32943069 Free PMC article.
Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia. Braun DJ, Bachstetter AD, Sudduth TL, Wilcock DM, Watterson DM, Van Eldik LJ. Geroscience. 2019 Oct;41(5):671-679. doi: 10.1007/s11357-019-00072-4. Epub 2019 May 19. PMID: 31104189 Free PMC article.
Blood Flow Deficits and Cerebrovascular Changes in a Dietary Model of Hyperhomocysteinemia. Braun DJ, Abner E, Bakshi V, Goulding DS, Grau EM, Lin AL, Norris CM, Sudduth TL, Webster SJ, Wilcock DM, Van Eldik LJ. ASN Neuro. 2019 Jan-Dec;11:1759091419865788. doi: 10.1177/1759091419865788. PMID: 31362539 Free PMC article.
In vivo Brainstem Imaging in Alzheimer’s Disease: Potential for Biomarker Development. Braun DJ, Van Eldik LJ. Front Aging Neurosci. 2018 Sep 11;10:266. doi: 10.3389/fnagi.2018.00266. eCollection 2018. PMID: 30254583 Free PMC article. Review.
Sex-related responses after traumatic brain injury: Considerations for preclinical modeling. Späni CB, Braun DJ, Van Eldik LJ. Front Neuroendocrinol. 2018 Jul;50:52-66. doi: 10.1016/j.yfrne.2018.03.006. Epub 2018 May 18. PMID: 29753798 Free PMC article. Review.